Reversal of sedative effect of benzodiazepines after anesthesia or short diagnosis procedures
Child: 0.01 mg/kg, max 0.2 mg IV over 15 sec. Repeat 0.01 mg/kg prn, max 0.2 mg after 45 sec then q 1 min to total dose of 0.05 mg/kg or 1 mg, whichever is lower.
Adult: 0.2 mg IV over 15 sec. If pt fails to reach desired level of consciousness after 45 sec, repeat q min until dose of 1 mg has been given. If resedation occurs, repeat dose after 20 min, max 1 mg/dose and 3 mg/h.
Suspected benzodiazepine overdose
Child: 0.01 mg/kg, max 0.2 mg IV over 15 sec. Repeat q min to total dose of 1 mg.
Adult: 0.2 mg IV over 30 sec. If pt fails to reach desired level of consciousness after 30 sec, 0.3 mg over 30 sec. If pt still fails to respond, give 0.5 mg over 30 sec; then repeat 0.5 mg doses q min until dose of 3 mg has been given. Max 5 mg over 5 min initially. If resedation occurs, repeat dose after 20 min; max 1 mg/dose and 3 mg/h. |