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| Interactions: | Alpha blockers: Antagonized vaso-constriction and hypertension. Monitor child closely.
Antidiabetics: May decrease effects. Dosage ad-justments may be necessary. Monitor serum glu-cose levels.
Antihistamines, thyroid hormones, tricyclic anti-depressants: May potentiate adverse cardiac ef-fects of epinephrine. Avoid concomitant use.
Beta blockers such as propranolol: Antagonized e cardiac and bronchodilating effects of epineph-rine. Monitor child closely.
Cardiac glycosides, general anesthetics (espe-cially cyclopropane, halothane): May sensitize myocardium to epinephrines effects, causing ar-rhythmias. Monitor child closely.
Ergot alkaloids, oxytocics: May cause severe hy-pertension. Monitor blood pressure; avoid con-comitant use.
Guanadrel, guanethidine: May decrease drugs hypotensive effects while potentiating epineph-rines effects, resulting in hypertension and ar-rhythmias. Monitor child closely.
Levodopa: May enhance risk of cardiac arrhyth-mias. Monitor child closely.
MAO inhibitors: Increased risk of hypertensive crisis. Monitor blood pressure; avoid concomitant use.
Miotics: Reduced ciliary spasm, mydriasis, blurred vision, and increased intraocular pressure that may occur with miotics or epinephrine alone. Use for therapeutic effect.
Ophthalmic epinephrine with carbonic ahd nyrase inhibitors, osmotic drugs, topical beta blockers, topical miotics: May cause additive lowering of intraocular pressure. Monitor child.
Phenothiazines: May cause reversal of epi-nephrines pressor effects; dont use epinephrine for circulatory collapse or hypotension caused by phenothiazines; such use may cause further low-ering of blood pressure. Monitor blood pressure closely.
Sympathomimetics: May produce additive effects and toxicity. Avoid concomitant use. |
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