Respiratory, skin and soft-tissue infection; UTI; septicemia, meningitis
Infant, > child 3 month: 50-100 mg/kg/day IM or IV in divided doses q 6-8 h. Some give 100-150 mg/kg/day. For meningitis, 200-240 mg/kg/day IV in divided doses q 6-8 h, reduced to 100 mg/kg/day when improvement.
Adolescent, adult: 750 mg-1.5 gram IM or IV q 8 h × 5-10 day. For life-threatening or infection caused by less susceptible organisms, 1.5 gram IM or IV q 6 h; for bacterial meningitis, up to 3 gram IV q 8 h.
Pharyngitis, tonsillitis, respiratory infection, UTI
Infant, child 3 month-12 yr: 20 mg/kg/day oral susp in divided doses bid; max 500 mg/day × 10 day. Child < 12 yr who can swallow pills: 125 mg tab PO bid × 10 day.
Adolescent, adult: 125-250 mg PO bid × 10 day.
OM, impetigo
Infant, child 3 month-12 yr: 30 mg/kg/day PO oral susp in 2 divided doses (max 1 gram) × 10 day. Child who can swallow pills: 250 mg PO bid × 10 day.
Perioperative prophylaxis
Adult: 1.5 gram IV 30-60 min before surgery; then 750 mg IM or IV q 8 h intraoperative for long surgery.
Gonorrhea
Adult: 1.5 gram IM (with PO probenecid) in 1 dose, alone or with other antibiotics.
Lyme disease
Adolescent = 13 yr, adult: 500 mg PO bid × 20 day. |