Drug-drug.
Ammonium chloride, other urine acidifiers: Increased aspirin blood levels. Watch for aspirin toxicity.
Antacids in high doses, other urine alkalizers: Decreased aspirin blood levels. Watch for de-creased salicylate effect.
Anticoagulants, thrombolytics: May potentiate platelet-inhibiting effects of aspirin. Use togeth-er cautiously.
Corticosteroids: Enhances aspirin elimination. Avoid concomitant use.
Highly protein-bound drugs (phenytoin, sulfonyl-ureas, warfarin): May cause displacement of ei-ther drug and adverse effects. Monitor therapy closely for both drugs.
Lithium carbonate: Decreases renal clearance of lithium carbonate, thus increasing serum lithium levels and risk of adverse effects. Avoid concur-rent use.
Other GI irritant drugs (such as antibiotics, corti-costeroids, other NSAIDs): May potentiate adverse GI effects of aspirin. Use together with caution.
Other ototoxic drugs (such as aminoglycosides, bumetanide, capreomycin, cisplatin, ethacrynic acid, erythromycin, furosemide, vancomycin): May potentiate ototoxic effects. Use together cautiously.
Phenylbutazone, probenecid, sulfinpyrazone: An-tagonistic to uricosuric effects. Avoid concomi-tant use.
Drug-food. Any food:
Delays and decreases ab-sorption of aspirin. Advise patent to take without food to increase absorption. |