Drug-drug.
Allopurinol: Appears to increase risk of rash from both drugs. Use together cau-tiously.
Methotrexate: Large doses of penicillins may in-terfere with renal tubular secretion of methotrex-ate, delaying elimination and prolonging elevat-ed serum levels of methotrexate.Monitor levels.
Oral contraceptives: Concomitant use may reduce contraceptive effectiveness. Recommend alternative birth control method.
Probenecid: Blocks tubular secretion of amoxi-cillin, raising its serum levels; has no effect on clavulanate. |