Benazepril
Adverse Effect: hyperkalemiaClinical Management: Although such increases are usually transient, monitor serum potassium levels for persistent elevations in patients on this combination, especially in patients with renal dysfunction or diabetes and the elderly. Severe arrhythmias and death have been reported from hyperkalemia with such combinations.
Captopril
Adverse Effect: hyperkalemia Clinical Management: Although such increases are usually transient, monitor serum potassium levels for persistent elevations in patients on this combination, especially in patients with renal dysfunction or diabetes and the elderly. Severe arrhythmias and death have been reported from hyperkalemia with such combinations.
Celecoxib
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Celecoxib and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Diclofenac Preps.
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering nonsteroidal antiinflammatory agents (NSAIDs) and potassium sparing diuretics concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Digoxin
Adverse Effect: decreased digoxin effectiveness Clinical Management: Monitor patients for reduced therapeutic effect of digoxin.
Enalapril
Adverse Effect: hyperkalemia Clinical Management: Although such increases are usually transient, monitor serum potassium levels for persistent elevations in patients on this combination, especially in patients with renal dysfunction or diabetes and the elderly. Severe arrhythmias and death have been reported from hyperkalemia with such combinations.
Flurbiprofen
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Flurbiprofen and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Ibuprofen
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Ibuprofen and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Ibuprofen Comb.
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Comb. Ibuprofen and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Indomethacin
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Indomethacin and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Ketoprofen
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Ketoprofen and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Ketorolac
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Ketorolac and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Lisinopril
Adverse Effect: hyperkalemia Clinical Management: Although such increases are usually transient, monitor serum potassium levels for persistent elevations in patients on this combination, especially in patients with renal dysfunction or diabetes and the elderly. Severe arrhythmias and death have been reported from hyperkalemia with such combinations.
Lithium
Adverse Effect: increased lithium concentration and lithium toxicity (weakness, tremor, excessive thirst, confusion) Clinical Management: Monitor serum lithium levels within the first five to seven days of adding or discontinuing amiloride and periodically thereafter. Changes in the lithium dose may be required with concomitant amiloride therapy.
Mefenamic Acid
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Mefenamic Acid and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Meloxicam
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Meloxicam and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels
Metformin
Adverse Effect: an increased risk of lactic acidosis Clinical Management: In patients receiving metformin and Amiloride , closely monitor blood glucose concentrations. Metformin doses may need to be reduced.
Nabumetone
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Nabumetone and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels
Naproxen
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Naproxen and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Nimesulide
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Nimesulide and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Oxyphenbutazone
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Oxyphenbutazone and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Paracetamol
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Paracetamol and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Paracetamol Comb.
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Comb. Paracetamol and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Perindopril
Adverse Effect: hyperkalemia Clinical Management: Although such increases are usually transient, monitor serum potassium levels for persistent elevations in patients on this combination, especially in patients with renal dysfunction or diabetes and the elderly. Severe arrhythmias and death have been reported from hyperkalemia with such combinations.
Phenacetin
Adverse Effect: Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Phenacetin and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Phenylbutazone
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Phenylbutazone and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Piroxicam
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Piroxicam and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels.
Quinidine
Adverse Effect: an increased risk of arrhythmias in patients with ventricular tachycardia Clinical Management: Patients receiving quinidine therapy should avoid the use of amiloride.
Ramipril
Adverse Effect: hyperkalemia Clinical Management: Although such increases are usually transient, monitor serum potassium levels for persistent elevations in patients on this combination, especially in patients with renal dysfunction or diabetes and the elderly. Severe arrhythmias and death have been reported from hyperkalemia with such combinations.
Tenoxicam
Adverse Effect: reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Clinical Management: When administering Tenoxicam and Amiloride concurrently, monitor the patient for decreased effectiveness of the diuretic and hyperkalemia. Monitor blood pressure, weight changes, urine output, potassium levels, and creatinine levels. |