Hyperuricemia secondary to malignancies Child < 6 yr: 50 mg PO tid.
Child 6-10 yr: 100 mg PO tid.
Prevention of uric acid nephropathy during CA chemotherapy Child: 200 mg/m2 IV qd or in equally divided infusion q 6, 8 or 12 h starting 1-2 day before chemotherapy.
Adult: 600-800 mg PO qd × 2-3 day starting 1-2 day before chemotherapy. Or 200-400 mg/m2 IV qd or in equally divided infusion q 6, 8, or 12 h starting 1-2 day before chemotherapy. Max 600 mg/day. |