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| Interactions: | PhenytoinAdverse Effect: decreased phenytoin plasma concentrations and potential increased seizure activityClinical Management: Monitor patients for reduction in antiepileptic plasma levels. Consider alternative antiviral therapy.
ProbenecidAdverse Effect: Increased acyclovir serum concentrationsClinical Management: No changes in acyclovir dosage appear to be necessary.
Sodium ValproateAdverse Effect: decreased valproic acid plasma concentrations and potential increased seizure activityClinical Management: Monitor patients for reduction in antiepileptic plasma levels. Consider alternative antiviral therapy.
ZidovudineAdverse Effect: Increased lethargy and fatigue Clinical Management: Patients should be warned about excessive fatigue which may occur with concurrent use. If severe, bed rest is advised. |
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