Amphotericin B, diuretics: Enhanced hypokalemia. Monitor serum potassium levels closely. Antacids, cholesryramine, colestipol: Decreased corticosteroid effect; corticosteroid is adsorbed, decreasing amount absorbed. Monitor child closely.
Anticholinesterase: Possible profound weakness. Monitor child.
Barbiturates, phenytoin, rifampin: Decreased cor-ticosteroid effects due to increased hepatic me-tabolism. Increase corticosteroid dose as ordered.
Cardiac glycosides: Increased risk of toxicity. Monitor glycoside levels.
Cyclosporine: Levels may increase. Monitor drug levels.
Estrogens: Reduced metabolism of corticoste-roids. Monitor child closely.
Insulin, oral antidiabetics: Cause hyperglycemia. Monitor serum glucose levels; may need dosage adjustment.
Isoniazid, salicylates: Glucocorticoids increase metabolism of these drugs. Monitor child for lack of effect.
NSAIDs: May increase risk of GI ulceration. Give together cautiously
Oral anticoagulants: Adrenocorticoids may de-crease effects of these drugs. Monitor child closely.
Skin test antigens: Decreased response. Defer test until after therapy.
Vaccines: Drug may decrease effectiveness. Avoid concomitant use. |