Amitriptyline Adverse Effect Blood pressure elevationClinical Management Monitor blood pressure carefully during concurrent therapy; consider use of alternative antihypertensive agent if more conventional agents (ACE inhibitors, calcium antagonists) are not already being used. Tricyclic antidepressants generally are not effective in relieving drug-induced depression which may be encountered with methyldopa
AtenololAdverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
BetaxololAdverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
BisoprololAdverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
Carvedilol Adverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
CeliprololAdverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
Esmolol Adverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
Haloperidol Adverse Effect CNS toxicity (dementia) or reversible parkinsonismClinical Management Monitor psychiatric symptoms. Discontinue haloperidol if necessary.
Labetalol Adverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
Levobunolol Adverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
LevodopaAdverse Effect Altered response to levodopa and/or enhanced hypotensive effectClinical Management Monitor the patient for continuing beneficial or even enhanced parkinsonian response to levodopa; some dosage reduction may be possible. Generally mild additive hypotensive effects may manifest which might require adjustment of methyldopa dosage.
Lithium Adverse Effect An increased risk of lithium toxicity (tremor, weakness, excessive thirst, confusion)Clinical Management Monitor for signs of neurotoxicity with concomitant therapy; serum lithium levels may not necessarily predict this effect. An alternative antihypertensive agent might be considered.
Metoprolol Adverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
OxprenololAdverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
PindololAdverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
Propranolol Adverse Effect exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
SelegilineAdverse Effect hypertensive crisis (headache, palpitation, neck stiffness)Clinical Management: The concurrent use of methyldopa and Selegiline is contraindicated.
SotalolAdverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physical stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine.
TimololAdverse Effect Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholaminesClinical Management Monitor blood pressure carefully during concurrent therapy, especially during excessive physiologic stress or use of exogenous catecholamines such as phenylpropanolamine. |