Antacids containing aluminum, lax-atives: Decreased oral absorption. Anticoagulants: May increase anticoagulant ac-tivity. Monitor PT and INR closely.
Benzodiazepines (such as diazepam), carba-mazepine, phenytoin: INH-induced inhibition of metabolism and elevation of serum levels. Mon-itor child closely.
Corticosteroids: May decrease INH efficacy. Mon-itor child closely.
Cycloserine: Increased hazard of CNS toxicity, drowsiness, and dizziness. Avoid concomitant use.
Disulfiram: Possible coordination difficulties and psychotic episodes. Avoid concomitant use.
Rifampin: May accelerate tNH metabolism to he-patotoxic metabolites. Monitor liver function tests. |