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| Interactions: | AtorvastatinAdverse Effect: Myopathy including RhabdomyolysisClinical Management: Monitor for the adverse effects and HMG-CoA reductase inhibitors like Atorvastatin/Cerivastatin should be used with caution.
DidanosineAdverse Effect: Absorption of both drugs will be hindered if administered togetherClinical Management: Indinavir should be administered on an empty stomach at least 1 hour before Didanosine.
DiltiazemAdverse Effect: increase in the Plasma concentration of Calcium Channel Blockers like Diltiazem due to inhibition of cytochrome P450 3A4Clinical Management: Monitor for the adverse effect and administer the drugs with caution.
EfavirenzAdverse Effect: Decrease in plasma concentration of IndinavirClinical Management: Indinavir dose has to be increased to 1000 mg every 8 hours when given with Efavirenz.
FelodipineAdverse Effect: increase in the Plasma concentration of Calcium Channel Blockers like Felodipine due to inhibition of cytochrome P450 3A4Clinical Management: Monitor for the adverse effect and administer the drugs with caution.
ItraconazoleAdverse Effect: Increase in the Plasma concentration of IndinavirClinical Management: Monitor for therapeutic effect and decrease the dose of Indinavir if required.
KetoconazoleAdverse Effect: increase in the Plasma concentration of IndinavirClinical Management: Monitor for therapeutic effect and decrease the dose of Indinavir if required.
NevirapineAdverse Effect: Decrease in plasma concentration of IndinavirClinical Management: Clinical effects is not known, adjust the dose accordingly.
RifampicinAdverse Effect: decrease in the Plasma concentration of Indinavir markedlyClinical Management: Avoid the concomitant use if possible.
VerapamilAdverse Effect: increase in the Plasma concentration of Calcium Channel Blockers like Verapamil due to inhibition of cytochrome P450 3A4Clinical Management: Monitor for the adverse effect and administer the drugs with caution. |
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