ORAL: 100mg/day for 6 months to 2 years.
ADULTS < 35kg: 50mg/day or 1-2mg/kg/day.
MULTIBACILLIARY LEPROSY: 50mg/day + 600mg Rifampicin once a month + 300mg Clofazimine once a month.
PAUCIBACILLIARY LEPROSY: 50mg/day + 600mg Rifampicin once a month.
DERMATITIS HERPETIFORMIS: Start with 50mg/day and increase upto 400mg till full response obtained. Dose reduced to a minimum maintenance level as soon as possible. This could be as low as 50mg weekly.
Leprosy
Child: 1-1.5 mg/kg PO qd. Adult: 100 mg PO qd for at least 2 yr, plus rifampin 600 mg qd × 6 month.
Prophylaxis for leprosy pts close contacts
Infant < 6 month: 6 mg PO 3 times/wk.
Infant, child 6-23 month: 12 mg PO 3 times/wk.
Child 2-5 yr: 25 mg PO 3 times/wk.
Child 6-11 yr: 25 mg PO qd.
Child = 12 yr, adult: 50 mg PO qd.
Dermatitis herpetiformis
Adult: 50 mg PO qd, increase prn to obtain full control. Pts with high acetylation rates may need dose adjusted.
Malaria suppression or prophylaxis
Child: 2 mg/kg PO q wk, with pyrimethamine 0.25 mg/kg/wk.
Adolescent, adult: 100 mg PO q wk, with pyrimenthamine 12.5 mg PO q wk. Cont prophylaxis throughout exposure and 6 month postexposure.
Pneumocystis carinii pneumonia
Adult: 100 mg PO qd. Usually with trimethoprim (20 mg/kg qd in 4 divided doses) × 21 day.
Prophylaxis of P. carinii pneumonia for pt intolerant to cotrimoxazole
Infant, child > 1 month: 1 mg/kg PO qd. Max 100 mg PO qd.
Adolescent, adult: 50-100 mg PO qd. |