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	| Interactions: |  Atenolol
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management:If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
  Bisoprolol
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
  Celiprolol 
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (Atenolol, Metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
  Chlorpropamide 
  Adverse Effect: An increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Chlorpropamide. Doses of either or both drugs may need to be adjusted to minimize hypoglycemic effects.
  Digoxin 
  Adverse Effect: decreased digoxin efficacyClinical Management: Patients receiving digoxin and acarbose therapy should be instructed to take their medications consistently at the same time interval daily to avoid any fluctuations in their digoxin levels.
   Glibenclamide 
  Adverse Effect: An increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Glibenclamide . Doses of either or both drugs may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
  Gliclazide
  Adverse Effect: An increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Gliclazide . Dose of either or both drugs may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
  Glipizide 
  Adverse Effect: An increased risk of hypoglycemia Clinical Management:Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Glipizide . Dose of either or both drugs may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
  Insulin Lispro 
  Adverse Effect: increased risk of hypoglycemia Clinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from therapy. Doses of either or both acarbose and insulin may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
  Insulins - Lente / Zn 
  Adverse Effect: Increased risk of hypoglycemiaClinical Management:Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from therapy. Doses of either or both acarbose and insulin may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets or glucose liquid rather than food products which may contain sucrose. Sucrose is not effective in rapidly correcting hypoglycemia in acarbose-treated patients. Acarbose inhibits the hydrolysis of sucrose to glucose and fructose.
  Insulins - NPH / Isophane 
  Adverse Effect: Increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from therapy. Doses of either or both acarbose and insulin may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets or glucose liquid rather than food products which may contain sucrose. Sucrose is not effective in rapidly correcting hypoglycemia in acarbose-treated patients. Acarbose inhibits the hydrolysis of sucrose to glucose and fructose.
  Insulins - Neutral Soluble 
  Adverse Effect: Increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from therapy. Doses of either or both acarbose and insulin may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets or glucose liquid rather than food products which may contain sucrose. Sucrose is not effective in rapidly correcting hypoglycemia in acarbose-treated patients. Acarbose inhibits the hydrolysis of sucrose to glucose and fructose. 
  Insulins - Premixed Biphasic 
  Adverse Effect:Increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from therapy. Doses of either or both acarbose and insulin may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets or glucose liquid rather than food products which may contain sucrose. Sucrose is not effective in rapidly correcting hypoglycemia in acarbose-treated patients. Acarbose inhibits the hydrolysis of sucrose to glucose and fructose.
  Metoprolol
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
  Oxprenolol 
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
  Pindolol 
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertensionClinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided. 
  Propranolol 
  Adverse Effect: hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided. 
  Tolbutamide 
  Adverse Effect:An increased risk of hypoglycemiaClinical Management: Monitor closely blood glucose concentrations when Acarbose is added to or withdrawn from Tolbutamide . Dose of either or both drugs may need to be adjusted to minimize hypoglycemic effects. Patients receiving these medications should be counselled to carry a supply of glucose tablets.
  Warfarin 
  Adverse Effect: An increased risk of bleeding Clinical Management: Closely monitor the international normalized ratio (INR) following initiation or discontinuation of acarbose therapy in patients previously stabilized on warfarin. |  
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