Aluminum hydroxide antacid: De-creased GI absorption. Separate administration times.
Antidiabetics, insulin: Altered dosage require-ments in previously stable cabetic children. Mon-itor serum glucose level.
Atropine, tricyGic antidepressants, other drugs with anticholinergic effects: Possible antagonized propranolol-induced bradycardia. Monitor child closely.
Calcium channel blockers (especially L V. vera-pamil): Depressed myocardial contractility or AV conduction. Rarely, concurrent LV. use of a beta blocker and verapamil has resulted in serious ad-verse reactions, especially in children with severe cardiomyopathy heart failure, or recent MI. Use together cautiously.
Cimetidine: Decreased clearance of propranolol via inhibition of hepatic metabolism. Watch for enhanced beta-blocking effects.
Epinephrine: Severe vasoconstriction. Monitor blood pressure and observe child carefully.
NSAIDs: Possible antagonized hypotensive ef-fects. Monitor child closely.
Phenytoin, rifampin: Accelerated clearance of propranolol. Adjust dosage as needed.
Sympathomimetics (such as isoproterenol, MAO inhibitors): Antagonized beta-adrenergic stimulating effects. Monitor child closely.
Tubocurarine and related compounds: High dos-es of propranolol may potentiate neuromuscular blocking effect. Monitor child closely.
Other antihypertensives (especially catechola-mine-depleting drugs such as reserpine): Po-tentiated antihypertensive effects. Monitor blood pressure. |