Infection-
Neonate < 1 wk and < 2 kg: 50 mg/kg IM, IV q 12 h.
Neonate < 1 wk and = 2 kg: 50 mg/kg IM, IV q 8 h.
Neonate > 1 wk and = 2 kg: 50 mg/kg IM, IV q 8 h.
Neonate > 1 wk and = 2 kg: 50 mg/kg IM, IV q 6 h.
Infant, child 1 month-12 yr: 50 mg/kg IV over 30 min q 4 h.
Child 3-14 yr: 1.5 gram/m2 IV over 30 min q 4 h.
Child > 12 yr, adult : Serious infection: 12-18 gram/day IV in divided doses q 4-6 h; UTI, community-acquired pneumonia: 6-8 gram/day IV in divided doses q 6-12 h; complicated UTI: 8-16 gram/day IV in divided doses q 6-8 h; gonorrhea: 2 gram IM in 1 dose. Max 24 gram qd.
Prophylaxis of surgery infection-
Adult: intra-abdominal surgery: 2 gram IV preoperative, 2 gram perioperative, and 2 gram q 6 h postoperative × 24 h max; vag hysterectomy: 2 gram IV preoperative, 2 gram 6 h after 1st dose, then 2 gram 12 h after 2nd dose; c-section: 2 gram IV after cord clamped, then 2 gram q 4 h × 2 doses; abdominal hysterectomy; 2 gram IV preoperative: 2 gram in postanesth care unit, 2 gram after 6 h. |