Infection-
Infant, child 1 month-12 yr: 15-62.5 mg/kg (25,000-100,000 U/kg) PO qd in divided doses q 4-8 h.
Adolescent, adult: 125-250 mg PO q 6-8 h, or 500 mg PO q 12 h × 10 day. Severe infection: 250-500 mg PO q 6 h while pt afebrile × 2 day.
Group A streptococci pharyngitis, prevention of rheumatic fever-
Child: 250 mg PO bid-tid × 10 day.
Adolescent, adult: 500 mg PO bid-tid × 10 day.
Endocarditis prophylaxis-
Child < 30 kg: ½ adult dose.
Adult: 2 gram PO 30-60 min before procedure, then 1 gram 6 h later.
Necrotizing ulcerative gingivitis-
Child = 12 yr, adult: 250-500 mg PO q 6-8 h.
Lyme disease-
Child < 9 yr: 25-50 mg/kg PO qd in 3 divided doses × 10-30 day.
Adult: 250-500 mg PO qid × 10-20 day.
Prophylaxis for pneumococcal infection in pt with asplenia-
Child < 5 yr: 125 mg PO bid.
Child = 5 yr: 250 mg PO bid. |