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| Interactions: | Cimetidine Adverse Effect Decreased cimetidine effectivenessClinical Management Concurrent administration of cimetidine and metoclopramide is not recommended. Administer the cimetidine dose at least two hours before the metoclopramide dose.
Cyclosporin Adverse Effect Increases Cyclosporine concentrationsClinical Management: Monitor Cyclosporine concentrations and adjust the dosage accordingly.
Digoxin Adverse Effect decreased digoxin effectivenessClinical Management Metoclopramide appears to have no effect on the absorption of rapidly dissolving preparations of digoxin (ie, Lanoxin(R) tablets, Lanoxicaps(R), or elixirs). Switching to a rapidly dissolving preparation may be advisable if receiving another brand.
Dopamine Clinical Management: No additional precautions or monitoring appears necessary during concurrent use of metoclopramide and dopamine
LevodopaAdverse Effect Increased levodopa bioavailability and an increased incidence of extrapyramidal symptomsClinical Management While metoclopramide can increase the bioavailability of levodopa, these two drugs should generally not be given concurrently since metoclopramide may cause parkinsonian-like symptoms.
Sertraline Adverse Effect Increased risk of developing extrapyramidal symptomsClinical Management Clinicians should be alerted to the possibility that patients may have an increased risk of experiencing extrapyramidal symptoms during coadministration of sertraline and metoclopramide. Close patient monitoring is warranted.
Succinyl CholineAdverse Effect prolonged neuromuscular blockadeClinical Management Monitor patients for slower recovery times from neuromuscular blockade.
Thiopentone Sodium Adverse Effect enhanced hypnotic effect of thiopentalClinical Management Monitor the patients degree of sedation. Lower doses of thiopental may be required. |
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