Hyaluronidase Adverse Effect: an increased incidence of a systemic reaction to the anesthetic Clinical Management: Monitor patients for local anesthetic toxicity. Hyaluronidase effectively increases topical diffusion of local anesthetics. However, due to its propensity to increase the incidence of systemic reactions to local anesthetics and because there are newer anesthetic agents which penetrate very effectively, its use can no longer be justified. |