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| Interactions: | Anticoagulants: May alter anticoagulant effect. Increase in levothyroxine dosage may need a decrease in anticoagulant dosage. Monitor PT and INR.
Beta blockers: Decreased conversion of levothyroxine to liothyronine. Use with caution.
Cholestyramine: Delayed absorption of levothyroxine. Separate administration times by 4 to 5 hours.
Corticotropin: Concomitant use causes changes in thyroid status. Corticotropin dose may need adjustment.
Estrogens: Decreased free levothyroxines. Watch for decreased effectiveness o1 thyroid hormone.
Hepatic enzyme inducers (such as phenytoin): May increase hepatic degradation of levothyroxine. Increased dosage requirements of levothyroxine may be needed.
Insulin, oral antidiabetics: Altered serum glucose levels. Monitor serum glucose levels; dosage adjustments may be needed.
Sympathomimetics, tricyclic antidepressants: May increase effects of any or all of these drugs; possible coronary insufficiency or arrhythmias. Avoid concomitant use.
Theophylline: Decreased theophylline clearance in hypothyroid children. Monitor serum theophylline levels. |
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