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| Interactions: | Alprazolam Adverse Effect: Prolongation of Alprazolam clearance, which may lead to its accumulation and adverse effects
Clinical Management: Monitor for the adverse effects due to Alprazolam accumulation and adjust the dosage accordingly.
Diazepam Adverse Effect: Concomitant administration causes significant accumulation of Diazepam, which in turn causes serious adverse effects
Clinical Management: Avoid the concomitant administration if possible.
Melatonin Adverse Effect:Increased CNS depression
Clinical Management: Monitor for changes in sleep patterns as well as signs of excessive CNS depression. Downward titration of Melatonin dosage may be required during concomitant administration with Fluvoxamine.
MidazolamAdverse Effect: Prolongation of Midazolam clearance, which may lead to its accumulation and adverse effects
Clinical Management: Monitor for the adverse effects due to Midazolam accumulation and adjust the dosage accordingly.
Olanzapine Adverse Effect: Concomitant administration results in decreased clearance of Olanzapine due to the inhibition of CYP1A2
Clinical Management: Monitor for the therapeutic effects and adjust the dose accordingly.
Theophylline Adverse Effect: Concomitant administration results in significant reduction in the clearance of Theophylline (About 3 fold)
Clinical Management: In case of concomitant administration of these drugs Theophylline concentration should be reduced to one third of the usual daily maintenance dose and monitor its plasma concentration.
Warfarin
Adverse Effect: Considerable increase in the plasma concentration of Warfarin and prothrombin time
Clinical Management: Monitor the prothrombin time and adjust the anticoagulant dose if both these drugs are administered concomitantly. |
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