Adenosine
Adverse Effect: tachycardia Clinical Management: Monitor for an increase in heart rate or a decrease in blood pressure.
Cimetidine
Adverse Effect: Increased nicotine levels Clinical Management: Monitor for nicotine toxicity (eg, nausea and vomiting, diarrhea, abdominal pain, dizziness) and adjust the dose accordingly. If concurrent use cannot be avoided, select another H2-antagonist (eg, ranitidine or famotidine) that has less potential to alter drug metabolism.
Nicotinic Acid
Adverse Effect: Flushing and dizziness Clinical Management: If niacin and transdermal nicotine are used concurrently, the patient should be advised of the potential for this interaction.
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