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| Interactions: | Fluconazole Adverse Effect decreased conversion of losartan to its active metabolite (E-3174)Clinical Management Monitor patients for continued control of their hypertension.
LithiumAdverse Effect an increased risk of lithium toxicity (weakness, tremor, excessive thirst, confusion)Clinical Management Patients prescribed lithium and losartan should be closely monitored for the development of lithium toxicity. Plasma lithium levels should also be followed.
Phenobarbitone Adverse Effect Decreased losartan serum levelsClinical Management The coadministration of phenobarbital and losartan may result in a lowering of losartan plasma concentrations, but this effect is not considered to be clinically relevant.
Rifampicin Adverse Effect Reduced losartan efficacyClinical Management In patients receiving rifampin and losartan, monitor blood pressure and adjust the dose of losartan accordingly. |
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