Fluorouracil Adverse Effect fluorouracil toxicity (myelosuppression, stomatitis, GI toxicity)Clinical Management Fluorouracil plus leucovorin is routinely used therapeutically in the treatment of cancer. Monitor patients, especially the elderly, for increased toxicity (myelosuppression, stomatitis, GI toxicity).
Methotrexate Adverse Effect decreased efficacy of concurrently administered methotrexateClinical Management Methotrexate and leucovorin should not be administered concurrently. If leucovorin is being utilized as a folic acid rescue, therapy must be started after the administration of methotrexate.
PhenobarbitoneAdverse Effect decreased efficacy of phenobarbitalClinical Management Monitor the patient for seizure control if high doses of leucovorin are administered.
PrimidoneAdverse Effect decreased primidone efficacyClinical Management Monitor the patient for seizure control if high doses of leucovorin are administered. |