Suppressive prophylaxis of malaria
Child: 5 mg (base)/kg PO on same day once/wk (max 300 mg base) beginning 2 wk before exposure.
Adult: 500 mg phosphate (300-mg base) PO on same day once/wk beginning 2 wk before exposure.
Acute malaria
Child: 10 mg (base)/kg PO; then 5 mg (base)/kg after 6 h. 3rd dose is 5 mg (base)/kg 18 h after 2nd dose; 4th dose is 5 mg (base)/kg 24 h after 3rd dose; or 5 mg (base)/kg IM; repeat in 6 h prn. Change to PO ASAP.
Adult: 1 gram (600-mg base) PO then 500 mg (300-mg base) PO after 6 h; 3rd doses of 500 mg (300-mg base) PO 18 h after 2nd dose; 4th dose of 500 mg (300-mg base) 24 h after 3rd dose. Or 4-5 ml (160-200-mg base) IM; repeat in 6 h prn. Change to PO ASAP.
Extraintestinal amebiasis
Child: 10 mg (base)/kg PO qd × 2-3 wk; max 300 mg base qd.
Adult: 1 gram (600-mg base) PO qd × 2 day, then 500 mg (300-mg base) qd × 2-3 wk or 4-5 ml (160-200-mg base) IM × 10-12 day. Change to PO ASAP. |