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| Interactions: | Gentamicin
Adverse Effect: an increased risk of nephrotoxicity Adverse Effect: Coadministration of Gentamicin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Heparin
Adverse Effect: increased risk of bleeding Adverse Effect: Patients receiving heparin and cefoperazone concurrently should have careful monitoring of the anticoagulant therapy. In patients who are at high risk of bleeding, the use of an alternative antimicrobial agent would be advisable.
Neomycin
Adverse Effect: an increased risk of nephrotoxicity Adverse Effect: Coadministration of Neomycin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Netilmicin
Adverse Effect: an increased risk of nephrotoxicity Adverse Effect: Coadministration of Netilmicin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Probenecid
Adverse Effect: Cefoperazone toxicity (neuromuscular toxicity, CNS toxicity) Adverse Effect: If clinical symptoms of toxicity occur, reduce the dose of Cefoperazone .
Sisomicin
Adverse Effect: an increased risk of nephrotoxicity Adverse Effect: Coadministration of Sisomicin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Streptomycin
Adverse Effect: an increased risk of nephrotoxicity Adverse Effect: Coadministration of Streptomycin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Tobramycin
Adverse Effect: an increased risk of nephrotoxicity Adverse Effect: Coadministration of Tobramycin with Cefoperazone could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Warfarin
Adverse Effect: an increased risk of bleeding Adverse Effect: In patients receiving oral anticoagulant therapy with warfarin, the prothrombin time ratio or international normalized ratio (INR) should be closely monitored with the addition and withdrawal of treatment with cefoperazone, and should be reassessed periodically during concurrent therapy. Adjustments of the warfarin dose may be necessary |
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