Allopurinol
Adverse Effect: Allopurinol inhibits the principal pathway for detoxification of Azathioprine Clinical Management: Concomitant administration requires a dose reduction of Azathioprine to 1/3 or 1/4 of the usual dose.
Cotrimoxazole
Adverse Effect: Exaggerated leukopenia Clinical Management: Monitor for signs and symptoms of leukopenia & institute supportive therapy. |