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| Interactions: | Drug-drug.
Acidic drugs: In large doses (more than 2 g/day), may lower urine pH, causing renal tubular reabsorption of these drugs. Reduced dosage may be needed.
Basic drugs (such as amphetamines, tricyclic an-tidepressants): May cause decreased reabsorp-tion and therapeutic effect. Dosage may need ad-justment.
Dicumarol: Influences intensity and duration of anticoagulant effect. Monitor PT.
Ethinyl estradiol: May increase plasma levels of ethinyl estradiol. Monitor patient closely.
Iron: Concomitant use maintains drug in ferrous state and increases iron absorption in GI tract. A combination of 30 mg iron with 200 mg ascorbic acid is sometimes recommended.
Salicylates: Ascorbic acid uptake inhibited by leukocytes and platelets. Although no evidence exists that salicylates precipitate ascorbic acid de-ficiency, patients receiving high doses of salicylates with ascorbic acid supplements must be ob-served for symptoms of ascorbic acid deficiency. Sulfonamides: Concurrent use may cause crys-tallization. Avoid using together.
Warfarin: May inhibit anticoagulant effect. Moni-tor PT. |
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