|
| Interactions: | Adrenaline Adverse Effect: ventricular toxicity (ventricular arrhythmia)
Clinical Management: Monitor for arrhythmias.
Ephedrine Adverse Effect: cardiac arrhythmias
Clinical Management: The administration of ephedrine to a patient receiving a halogenated hydrocarbon such as halothane is contraindicated. The use of a pressor drug with less cardiac stimulating effects than ephedrine should be utilized in a patient who is receiving a myocardial sensitizing anesthetic.
Labetalol Adverse Effect: hypotension or decreased cardiac output
Clinical Management: If concurrent use of labetalol and an inhalation anesthetic is required, monitor cardiac function (ie, blood pressure, heart rate) carefully, particularly in patients with pre-existing cardiac dysfunction.
LevodopaAdverse Effect: Enhanced halothane cardiac sensitivity
Clinical Management: If general anesthesia is required, levodopa may be continued as long as the patient is able to consume fluids and oral medication. If therapy is temporarily discontinued, the usual daily dosage may be reinstituted as soon as the patient is able to take oral medications. If levodopa therapy is interrupted for a longer period, the dosage should be adjusted gradually; however, in many cases the patient can be rapidly titrated to the previous dose.
MidazolamAdverse Effect: potentiation of anesthetic effects of halothane
Clinical Management: The minimum alveolar concentration (MAC) of halothane required for generalized anesthesia is reduced in a dose-dependent manner by the intravenous administration of midazolam.
Propofol Adverse Effect: Propofol toxicity (respiratory depression)
Clinical Management: Monitor respiratory depression.
Succinyl CholineAdverse Effect: faster development of phase II block and tachyphylaxis and cardiac arrhythmias
Clinical Management: Patients receiving halothane and succinylcholine should be monitored for the depth of neuromuscular blockade and cardiac arrhythmias. Ample time for spontaneous recovery from neuromuscular blockade should be given.
TheophyllineAdverse Effect: cardiac toxicity (ventricular arrhythmias, cardiac arrest)
Clinical Management: Halothane should not be given to patients taking theophylline. Another agent that does not interact with theophylline, such as enflurane, should be considered as an alternative.
Verapamil Adverse Effect: depressed cardiovascular activity
Clinical Management: When used concomitantly, verapamil and halothane should each be carefully titrated to avoid excessive cardiovascular depression.
Warfarin Adverse Effect: Increased free-fraction of warfarin in vitro
Clinical Management: In patients receiving oral anticoagulant therapy with warfarin, the prothrombin time ratio or INR (international normalized ratio) should be closely monitored during the perioperative period after treatment with halothane. Adjustments of the warfarin dose may be necessary in order to maintain the desired level of anticoagulation. |
|
|