|
| Dosages: | Treatment of deep vein thrombosis: Dalteparin can be administered SC either as a single daily injection of 200 IU/ kg or as two daily injections of 100 IU/kg. The single daily dose should not exceed 18000 IU.
Thromboprophylaxis in conjunction with surgery: General surgery with associated risk of thromboembolic complications: 2500 IU administered subcutaneously 1 to 2 hours before the operation and thereafter 2500 IU subcutaneously each morning until the patient is mobilized, in general 5-7 days or longer.
General surgery associated with additional risk factors and orthopedic surgery: 5000 IU is given subcutaneously the evening before operation and 5000 IU subcutaneously the following evenings. Treatment is continued until the patient is mobilized, in general 5 to 7 days or longer. As an alternative 2500 IU is given subcutaneously within 2 hours before operation and 2500 IU subcutaneously 8 to12 hours later. On the following days 5000 IU subcutaneously each morning.
In orthopaedic surgery, post-operative thromboprophylaxis : 2500 IU is given subcutaneously no sooner than 4 hours post-operatively, followed by 5000 IU subcutaneously once daily, each morning.
Unstable coronary artery disease, i.e. unstable angina and non Q- wave myocardial infarction:120 IU/ kg body weight is administered subcutaneously twice daily. Maximum dose is 10000 IU/ 12 hours. Treatment should be continued for at least 6 days or longer if considered of benefit by the physician. Concomitant therapy with low dose acetylsalicylic acid is recommended.
Prevention of clotting during haemodialysis and hemofiltration in patients with chronic renal failure,patients with no known bleeding risk: 30-40 IU/kg IV followed by IV infusion of 10-15 IU/kg/hour if hemodialysis is for more than 4 hours.
If less than 4 hours: IV bolus injection of 5000 IU.
In patients with acute renal failure, patients with high bleeding risk:IV bolus injection of 5-10 IU/kg followed by IV infusion of 4-5 IU/kg/hour.
|
|
|