Carbamazepine
Adverse Effect: Decreased clobazam effectiveness Clinical Management: The clinical efficacy of both agents, as well as potential carbamazepine toxicity, should be monitored. An alternative benzodiazepine, such as clonazepam, which has not been reported to interact with carbamazepine might be considered.
Phenytoin
Adverse Effect: Increased risk of phenytoin toxicity (ataxia, hyperreflexia, nystagmus, tremor) Clinical Management: Monitor for signs of phenytoin toxicity with combined therapy; consideration might also be given to monitoring serum phenytoin levels.
Theophylline
Adverse Effect: decreased benzodiazepine effectiveness Clinical Management: Monitor the patient for benzodiazepine clinical effectiveness. A larger than usual Clobazam dose may be required. |