Acarbose
Adverse Effect: An increased risk of hypoglycemia Clinical Management: Monitor closely blood glucose concentrations when acarbose is added to or withdrawn from Chlorpropamide. Doses of either or both drugs may need to be adjusted to minimize hypoglycemic effects.
Aspirin
Adverse Effect: Hypoglycemia (CNS depression, seizures) Clinical Management: In patients receiving high doses of aspirin, monitor the patients blood glucose and monitor the patient for clinical signs of hypoglycemia. Adjust the dosage of chlorpropamide if necessary.
Atenolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Bisoprolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Carvedilol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Celecoxib
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Celecoxib is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Celecoxib is added to therapy.
Celiprolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Chloramphenicol
Adverse Effect: hypoglycemia (CNS depression, seizures) Clinical Management: Monitor blood glucose during the initiation and discontinuation of chloramphenicol. A longer dosing interval of chlorpropamide may be required when concurrent doses of greater than 2 grams of chloramphenicol are used per day.
Chlorthalidone
Adverse Effect: decreased chlorpropamide effectiveness Clinical Management: Monitor blood glucose with concurrent use. The chlorpropamide dose may need to be adjusted.
Clotrimazole
Adverse Effect: Enhanced hypoglycemic effects Clinical Management: Avoid the use of Clotrimazole in patients who are taking Chlorpropamide . If concomitant therapy is required, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Cotrimoxazole
Adverse Effect: enhanced hypoglycemic effects Clinical Management: Avoid the use of Chlorpropamide in patients who are taking Chlorpropamide . If concomitant therapy is required, closely monitor blood glucose. Emergency treatment of a hypoglycemic episode may be required.
Diclofenac Preps.
Adverse Effect: A possible increased risk of hypoglycemia Clinical Management: When nonsteroidal antiinflammatory agents (NSAIDs) are coadministered with a sulfonylurea drug, patients should be monitored more closely for hypoglycemia. Doses of the sulfonylurea may need to be reduced when NSAIDs are added to therapy.
Diltiazem
Adverse Effect: Hypoglycemia Clinical Management: Monitor patients for changes in the usual levels of blood glucose control upon initiation or discontinuation of Diltiazem . Consider an alternative class of agent such as ACE inhibitors in patients with diabetes.
Flurbiprofen
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Flurbiprofen is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Flurbiprofen is added to therapy.
Ibuprofen
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Ibuprofen is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Doses of Chlorpropamide may need to be reduced when Ibuprofen is added to therapy.
Indomethacin
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Indomethacin is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Indomethacin is added to therapy.
Ketoprofen
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Ketoprofen is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Ketoprofen is added to therapy.
Ketorolac
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Ketorolac is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Ketorolac is added to therapy.
Labetalol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Mefenamic Acid
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Mefenamic Acid is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Mefenamic Acid is added to therapy.
Meloxicam
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Meloxicam is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Meloxicam is added to therapy.
Metoprolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Nabumetone
Adverse Effect: A possible increased risk of hypoglycemia Clinical Management: When Nabumetone is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Nabumetone is added to therapy.
Naproxen
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Naproxen is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Naproxen is added to therapy.
Nimesulide
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Nimesulide is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Nimesulide is added to therapy.
Oxprenolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Oxyphenbutazone
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Oxyphenbutazone is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Oxyphenbutazone is added to therapy.
Paracetamol
Adverse Effect: A possible increased risk of hypoglycemia Clinical Management: When Paracetamol is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Doses of the Chlorpropamide may need to be reduced when Paracetamol is added to therapy. Phenacetin
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Phenacetin is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Phenacetin is added to therapy.
Phenylbutazone
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Phenylbutazone is coadministered with Chlorpropamide drug, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Phenylbutazone is added to therapy.
Phenytoin
Adverse Effect: Decreased chlorpropamide effectiveness Clinical Management: Monitor blood glucose control with combined therapy; routine adjustments in therapy do not appear necessary.
Pindolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Piroxicam
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Piroxicam is coadministered with Chlorpropamide , patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Piroxicam is added to therapy.
Propranolol
Adverse Effect: Hypoglycemia, hyperglycemia, or hypertension Clinical Management: If the use of a beta blocker is required in a diabetic, watch for decreased diabetic control by monitoring the patients glucose carefully. Cardioselective beta blockers (atenolol, metoprolol) cause less disturbance of glucose metabolism and less masking of hypoglycemic effects. Propranolol accounts for the majority of positive reports of an interaction and should clearly be avoided.
Rifampicin
Adverse Effect: decreased chlorpropamide effectiveness Clinical Management: Monitor the patients blood glucose during concurrent therapy with chlorpropamide and rifampin. The dosage of chlorpropamide may need to be increased after initiation of rifampin therapy and decreased when rifampin is discontinued.
Sodium Bicarbonate
Adverse Effect: decreased chlorpropamide effectiveness Clinical Management: Concurrent administration of chlorpropamide and sodium bicarbonate is not recommended. If concurrent use cannot be avoided, monitor blood glucose upon initiation of sodium bicarbonate.
Sulphadiazine
Adverse Effect: enhanced hypoglycemic effects
Tenoxicam
Adverse Effect: a possible increased risk of hypoglycemia Clinical Management: When Tenoxicam is coadministered with Chlorpropamide, patients should be monitored more closely for hypoglycemia. Dose of Chlorpropamide may need to be reduced when Tenoxicam is added to therapy. |