Antacids Comb.
Adverse Effect: decreased cefpodoxime effectiveness Clinical Management: Concurrent administration of cefpodoxime and antacids (including H2 blockers) is not recommended. If concurrent use cannot be avoided, cefpodoxime should be taken at least two to three hours before the antacid dose.
Famotidine
Adverse Effect: decreased cefpodoxime effectiveness Clinical Management: Alternative antibiotic therapy (eg, select another third generation cephalosporin or a second generation cephalosporin with similar activity) should be considered. If possible, switch to another anti-ulcer medication (eg, sucralfate) and take cefpodoxime at least two hours before the dose.
Gentamicin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Gentamicin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Neomycin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Neomycin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Netilmicin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Netilmicin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Probenecid
Adverse Effect: cephalosporin toxicity (neuromuscular toxicity, CNS toxicity) Clinical Management: If clinical symptoms of cephalosporin toxicity occur, reduce the dose of Cefpodoxime .
Sisomicin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Sisomicin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Streptomycin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Streptomycin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity.
Tobramycin
Adverse Effect: an increased risk of nephrotoxicity Clinical Management: Coadministration of Tobramycin with Cefpodoxime could produce additive nephrotoxic effects. Use of these agents should be avoided in patients with prior renal insufficiency. If coadministration of these two antibiotic classes is necessary, patients should be monitored for evidence of nephrotoxicity. |