Ethinyl Oestradiol + Methyltestosterone Comb.
Adverse Effect: an increased risk of tizanidine adverse effects Clinical Management: Monitor patients for excessive tizanidine adverse effects (asthenia, somnolence, dry mouth, increased spasm or tone, and dizziness).
Oestrogen + Progestogen Comb.
Adverse Effect: an increased risk of tizanidine adverse effects Clinical Management: Monitor patients for excessive tizanidine adverse effects (asthenia, somnolence, dry mouth, increased spasm or tone, and dizziness).
Phenytoin
Adverse Effect: Increased risk of phenytoin toxicity (ataxia, hyperreflexia, nystagmus, tremor) Clinical Management: Patients should be counselled on the possibility of increased phenytoin side effects such as nystagmus, ataxia, and drowsiness. If such side effects occur, a serum phenytoin level should be considered and the dosage adjustments made accordingly. |