Aminoglycosides: Synergistic ther-apeutic effects, chiefly against enterococci; this combination is most effective in enterococcal bac-terial endocarditis. However, drugs are physically and chemically incompatible inactivated when mixed or given together. Administer separately.
Clavulanate: Enhanced effect of penicillin G against certain beta-lactamase-producing bacteria. Clavulanate may be used for this purpose.
Heparin, oral anticoagulants:Increased risk of bleeding. Monitor PTT, PT and INR.
Methotrexate: Large doses of penicillin may in-terfere with renal tubular secretion of methotrex-ate; delayed elimination and elevated serum lev-els of methotrexate. Monitor child for toxicity.
NSAIDs, sulfinpyrazone: Prolonged penicillin half-life. Monitor child for clinical effectiveness.
Probenecid: Blocked tubular secretion of peni-cillin, raising its serum levels. Probenecid may be used for this purpose. |