Indinavir
Adverse Effect: Decrease in plasma concentration of Indinavir Clinical Management: Clinical effects is not known, adjust the dose accordingly.
Ketoconazole
Adverse Effect: Significant reduction in Ketoconazole plasma concentration, plasma concentration of Nevirapine is increased Clinical Management: Avoid the concomitant use as far as possible.
Rifampicin
Adverse Effect: Steady-state nevirapine trough plasma concentrations were reduced by 16% and 37% in patients, who received Rifabutin /Rifampin Clinical Management: Rifampin/ Rifabutin should only be used in combination with Nevirapine if clearly indicated and with careful monitoring. |